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Communication Dans Un Congrès Année : 2010

Main determinants of human influenza phylodynamics

Résumé

As stated in [1], three main mechanisms have been proposed to explain the particular phylodynamic patterns observed in human influenza viruses: - a short-lived full cross-immunity among viral strains [2], - a punctuated evolution of the hemagglutinin (HA) gene among antigenic types that are linked by a network of neutrally evolving sites [3] - a continuous reuse by the viruses of a limited number of antigenic combinations [4]. We present a general framework to determine which association of these hypotheses best explains influenza phylodynamics. As source-sink dynamics [5] and additional local heterogeneity [6] have been reported to be important factors for influenza evolution, we start by considering a worldwide metapopulation model where nodes are jointly considered incorporating contact networks. Using this complex framework, we derive different simple models to characterize the processes that lead to the observed phylodynamics patterns. Our finding reveal the key role of immune boosting, a mechanism where exposed individuals that do not contract infections nevertheless gain additional cross-protection. [
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Dates et versions

hal-02756070 , version 1 (03-06-2020)

Identifiants

  • HAL Id : hal-02756070 , version 1
  • PRODINRA : 41182

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Sébastien Ballesteros, A. Camacho, Elisabeta Vergu, Bernard Cazelles. Main determinants of human influenza phylodynamics. CMOD3 Conference on Computational and mathematical Population Dynamics 3, May 2010, Bordeaux, France. ⟨hal-02756070⟩
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